Hunters syndrome was originally discovered in 1917 but there have been some extreme changes in science to open new avenues to study the disease. Although there is not a cure for MPS 2 there are many ongoing projects that are trying new ideas to help treat the disorder. Cue the study of genomics!
What is Genomics?
How is this Helpful for MPS 2?
Short Video on Recombination
This video is slightly cheesy but helps to explain the process of recombination!
What is Genomics?
- Genomics is the study of genomes, essential the study of DNA sequences. DNA sequences hold all of the information on what makes you, you. Genomics has helped to sequence the entire Human Genome and much more. In order for us to make advances in treating genetic disease we must know where the problems occur. From genomics there have been many techniques created to help correct some of the errors we know about. Like anything in science though this is a series of trial and error.
How is this Helpful for MPS 2?
- Scientists are currently working on using recombinant DNA to be used as a treatment for MPS 2. Recombinant DNA is a technique that has emerged as a result of studying genomics because it can hold a specific piece of genetic information that can be delivered to the cells of the body.
- Scientist Pan et.al have been working on a project with "supercharged" cells that have been able to deliver high levels of lysosomal (area where damage is done) enzymes to patients with Hunters Syndrome. In their experiment they use a special type of transporter that brings in the new enzymes to help take down extra GAG. Patients who have participated in this project experienced lower levels of GAG as a result of this type of treatment, thus calming some of their symptoms of the disease.
Short Video on Recombination
This video is slightly cheesy but helps to explain the process of recombination!