Brief Disease Overview: Hunters Syndrome also called MPS 2 is a rare genetic disorder. This disorder is classified as an X-linked disorder, which makes it more common in males than females (males only receive one X chromosome). Hunters Syndrome is caused by a defect to the iduronate-2-sulfatase gene which is a protein that helps to break down wastes in the body. Due to the job of this protein MPS 2 becomes a wide spread disease throughout the patients body. Hunters Syndrome is classified into two different degrees of disease attuenated (less severe, click symptoms for more details) and severe. The age of onset for patients depends on the degree of disease that they have, if the patient is classified as severe signs may start as early as 2 years of age and for attuenated signs are not seen until late childhood.